During both mitotic and meiotic cell divisions, a plethora of mechanisms ensure that the intact unbroken genome is accurately transmitted to the progeny. In the mitotic cell division, daughter cells are genetically identical to the mother, whereas in meiosis the resulting gametes harbor half of the chromosome complement and display genetic variability.
During the life of the cells, their genomes are continuously exposed to numerous threats from different sources. These include unproper repair or detection of damaged DNA, unscheduled DNA transcription or replication, uncontrolled cell-cycle progression, epigenetic deregulation, or chromosome missegregation, among others. All these genomic insults can derive into mutations, gross chromosome rearrangements, aneuploidy and, ultimately, genomic instability. These are common pathological features that often lead to diseases, hereditary disorders, cancer and infertility.
All the repair and regulatory mechanisms that surveil genome integrity and dynamics share key aspects that are well conserved throughout evolution, from unicellular organisms to humans. Understanding the key steps from these conserved pathways is critical for future discoveries and the generation of knowledge; and undoubtedly, it provides the opportunity to transfer basic knowledge into biomedical and biotechnological advances with clinical, industrial or agricultural applications.
This meeting will bring together leading scientists from around the world to discuss the latest advances in the field of Regulation of Cell Division (mitosis and meiosis) in connection with the processes of DNA Replication, DNA Damage Response, Meiotic Recombination, Nuclear Dynamics and Chromosome Segregation, and the implications for human health.
Interaction between invited speakers and registered attendees will be encouraged in this meeting. We look forward to your participation!